Hi-Tech Pharmaceuticals Estrogenex Depot

Rated 4.82 out of 5 based on 84 customer ratings
84 Reviews
(85 customer reviews)


Hi-Tech Pharmaceuticals Estrogenex Depot is a nutritional supplement, available without a prescription, designed to normalize all hormone levels, yielding a wide spectrum of health and anti-aging benefits. Estrogenex Depot acts as an irreversible anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone.

In stock

SKU: 853598003010
SKU: 853598003010

ESTROGENEX - is a nutritional supplement, available without a prescription, designed to normalize all hormone levels, yielding a wide spectrum of health and anti-aging benefits.

ESTROGENEX - is a multi-pathway formulation that minimizes or eliminates the undesirable effects associated with an estrogen dominant environment.

ESTROGENEX - maintains the correct testosterone to estrogen ratios that yield the benefits associated with normal estrogen levels.

ESTROGENEX - acts as an irreversible anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone.

ESTROGENEX - may also play a role in long-term selective estrogen blocking and/or inhibition of selective estrogen signaling.

ESTROGENEX - may contribute to notable improvements in muscular growth and fat loss, in addition to its wide array of health and anti-aging benefits.

ESTROGENEX - is designed for: Normalization of all hormone levels, with specific tendencies toward testosterone dominance, in all aging males.

Prevention and reversal of Gynecomastia.

Adjunctive supplementation for men undergoing hormone replacement therapy to ensure that raising testosterone levels will not yield an undesirable increase in estrogen levels.

A natural, more effective alternative for traditional testosterone hormone replacement therapy.

Bodybuilders and athletes during and immediately after periods of anabolic steroid use for the purpose of stimulating endogenous testosterone production.

Testosterone: Free-Testosterone and Plasma Protein-Bound Testosterone

Testosterone exists in the blood in either an active (free) or unbound state (+-2%) or inactive state bound to one of two proteins: sex-hormone-binding-globulin (SHBG) (+-45%) or albumin (+-53%). Only when testosterone is in its free state can it directly interact with cellular receptors and exert its activity. SHBG preferentially binds to testosterone over estrogen. Higher levels of SHBG in women help to maintain higher estrogen to testosterone ratios. Increased estrogen leads to an increase in SHBG. Thus, lowering the level of SHBG allows for an increased level of free testosterone. Obviously, if testosterone finds it more difficult to locate available plasma proteins in the presence of the additional compound, more will be left in an unbound state.

The amount of free testosterone can be altered (increased) by the use of aromatase inhibitors (the less testosterone that is synthesized [aromatized] into estrogen, the more total testosterone) or inhibitors of the plasma proteins that bind into testosterone. Manipulating the tendency of a testosterone to exist in an unbound state is an effective way to alter the overall activity and potency of one?s overall testosterone levels. Higher levels of testosterone produce an enhanced anti-glucocorticoid effect, which yields an anti-catabolic, or more precisely, anti-proteolytic, effect on muscle cells. This indirect anabolic effect is the result of testosterone?s high affinity for binding with glucocorticoid receptors, thus blocking the normal messenger pathway that triggers protein release from muscle tissue. More free testosterone also likely results in higher concentrations of IGF-1 and IGF-1 receptor sites in skeletal muscle tissue. Correspondingly, lower testosterone also likely yields less IGF-1 production and a corresponding decrease in IGF-1 receptor sites. Lower free testosterone also likely means a weaker immune system.

The Synthesis (Aromatization) of Testosterone to Estrogen in Males and the Significance of Maintaining Correct Testosterone to Estrogen Ratios.

Although testosterone is considered to be a male hormone and estrogen a female hormone, both hormones exist in both males and females and serve important functions for both. Estrogen is a term that really represents a collection of female hormones, with estrone predominating. Since estrone is the estrogen that is normally in the highest concentration, it is an excellent marker for basic estrogen levels for that reason. At least three estrogens have multiple and overlapping functions. Men obtain their estrogen through the action of the aromatase, which synthesizes (aromatizes) testosterone into estrogen. However, when concentrations of estrogen become too high and/or the normal ratio of testosterone to estrogen decreases, the potential for the development of undesirable conditions arises. This includes the development of the female breast tissue (gynecomastia), increased body fat and water retention. Also, research suggests that DHT and prostate tissue growth have a direct connection to above normal estrogen elevations and reduced testosterone levels.

The ESTROGENEX - Mechanism of Action

The ESTROGENEX - proprietary formula was developed by combining naturally occurring aromatase inhibitors and inhibitors of the action of SHBG. The primary active ingredients in ESTROGENEX are Coumesterol and Chrysin. ESTROGENEX does not exert its action through any direct hormonal activity

Before ESTROGENEX, little success had been achieved using chrysin as an effective aromatase inhibitor because chrysin is poorly absorbed in the bloodstream. However, in addition to their own specific aromatase inhibiting and estrogen-blocking actions, the proprietary blend of other ingredients work in synergy with chrysin to maintain a stable estrogen environment. We also incorporated our proprietary delivery system called EXTEND-RX? to avoid competing with other hormones such as testosterone in the Aromatase Cytochrome P450.

It is believed that ESTROGENEX exerts its effects through several mechanisms of action, which can be classified into two groups:

  1. as an inhibitor of the aromatase enzyme responsible for the conversion of testosterone to estrogen and an inhibitor of the action of SHBG, and
  2. as a blocker of selective anabolic estrogen receptors and/or inhibitor of selective estrogen signaling.

Substances that are aromatase inhibitors block the action of the enzyme aromatase that converts testosterone to estrogen. Substances that act as an anti-estrogen are those that block the estrogen receptor. Thus, even though there is estrogen circulating in the blood, the estrogen cannot exert its effects because it is blocked from attaching to its estrogen receptor. The dietary supplement ESTROGENEX ? is a multi-pathway agent that exerts its influence by blocking various stages in the aromatase process and by inhibiting SHBG's action; an activity not clearly addressed by any of the aromatase inhibiting or anti-estrogen products. Further, it appears that the use of ESTROGENEX may result in long-term blocking of selective anabolic estrogen receptors and/or inhibition of selective estrogen signaling (these anabolic estrogens are those demonstrating the undesirable effects associated with breast cancer and gynecomastia). This activity has not been addressed by any known dietary supplements or pharmacological agents.

ESTROGENEX as an Elevator of Total Testosterone and Liberator of Free Testosterone

As a powerful aromatase inhibitor, ESTROGENEX also possesses notable testosterone stimulating properties. The aromatase inhibiting action reduces the signal that estrogen sends to the brain to suppress endogenous testosterone production (estrogen is a main feedback signal to control the release of testosterone, thus increasing the testicular output of testosterone). ESTROGENEX thus assists in resetting the body's level of its own natural testosterone production by regulating the activity of the hypothalamic-pituitary-testicular axis (HPTA), which constantly adjusts the body's production of testosterone to maintain target blood levels. Continued use of ESTROGENEX results in not only a significant reduction in the production of estrogen, but also a corresponding substantial increase in endogenous testosterone.

Only ESTROGENEX addresses all possible channels to estrogen maintenance and free testosterone elevation, which means optimal hormonal levels for muscle building, fat loss, and anti-aging support.


Discuss with your physician before taking if you have a medical condition or are taking any prescription medications. Stop use and discuss with your physician if any negative effects occur. Do not exceed the suggested dose. Do not take if pregnant or lactating. Must be 18 years old to use this product. Keep away from children. Do not use if the seal has been tampered with. Store in a cool, dry place.

Serving Size: 1 Capsule
Servings per container: 90

Amount per serving

Proprietary Blend – 625 mg
Brassaiopsis Glomerulata Extract, N-Benzoyl-L-Phenylalanine Methyl Ester, 7, 8-Benzoflavone, 8-Bromo-7-Methoxychrysin, 9-Hydroxy-Alpha-Naphthoflavone, Coumestrol Dimethyl Ether, Indole-3-Carbinol, Beta-Sitosterol, Stinging Nettle Extract, Muira Puama 20:1 Extract, Naringin

Other Ingredients:
Dextrose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Sodium Starch Glycolate, Starch, Triacetin, Titanium Dioxide, Silica, FD&C Red #3, FD&C Yellow #6

Global Disclaimer

Manufacturers continually change product specifications, descriptions and ingredients. While we try our best to keep all product information up to date, it may not reflect the latest information available from the manufacturer. Product packaging may contain different or additional information, including the product description, nutritional facts, ingredients, allergens and other information. Always read labels, warnings, and directions and other information provided with the product before using or consuming a product. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. For additional information about a product, please contact the manufacturer.

Take three tablets of Estrogenex daily. Estrogenex is best taken near mealtime.

Additional information

Weight 4 oz
Dimensions 4.5 × 2 × 2 in

85 reviews for Hi-Tech Pharmaceuticals Estrogenex Depot

  1. Rated 5 out of 5
    84 Reviews


    Product works exceptionally well. I thought this was just going to be some overhyped bullshit.. But I can feel that its workin. I started noticing signs of my test levels increase in about a week in. Stuff fairly cheap too.

  2. Rated 5 out of 5
    84 Reviews


    Estrogenex is great at balancing my body’s estrogen levels to a point where I am able to maintain muscularity and vitality. My strength gains are steady and my overall confidence is up.

  3. Rated 5 out of 5
    84 Reviews

    tyler hart

    this stuff literally mkes you feel your estrogen getting regulated daytime, when u wake up in the morning, before youi go to bed, i used this as my pct from methyl1d black and i actually have less gyno then before i startyed my cycle. will never take another anti-estrogen!!

  4. Rated 5 out of 5
    84 Reviews

    tyler hart

    this stuff literally mkes you feel your estrogen getting regulated daytime, when u wake up in the morning, before you go to bed, i used this as my pct from methyl1d black and i actually have less gyno then before i startyed my cycle. will never take another anti-estrogen!!

  5. Rated 5 out of 5
    84 Reviews


    This product is great for anyone taking a Test Boost. It says it keeps estrogen levels in check. All i can tell you is i’m using the same test boost i always use and now after being on estrogenex for a month it feels like i doubled my dosage, and like i’m pumped up all day long. Great product and relatively inexpensive.

  6. Rated 4 out of 5
    84 Reviews

    Jay plap

    All thought you won’t feel the effects of this product alone it is a great idea to stack with any ph or gear that you run.

  7. Rated 4 out of 5
    84 Reviews


    I have been able to tell some positive effects from this product since I have been taking it. Its not something that you will take and immediately start to feel or notice it working.
    Does it work? Yes
    Would I buy it again? Yes

  8. Rated 5 out of 5
    84 Reviews


    love this stuff best ever I started getting tender nipples took this went away the end works well

  9. Rated 5 out of 5
    84 Reviews


    very good product take the puffiness of my nipples and yes I will buy this product again when I’m on a cycle

  10. Rated 5 out of 5
    84 Reviews


    thank you . will do business again.

  11. Rated 5 out of 5
    84 Reviews

    Swoll brother

    Good product has little acne at start of cycle cleared up nice after starting

  12. Rated 4 out of 5
    84 Reviews


    I used this product on cycle and Pct, it has helped keep the estrogenic side effects away, I would recommend to anyone who doesn’t want estrogenic side effects.

  13. Rated 5 out of 5
    84 Reviews


    Loved it!

  14. Rated 5 out of 5
    84 Reviews


    Great product for a low price. Product for a low price you get a lot traded with your restaurant dropping that could really tell that was happening here.

  15. Rated 5 out of 5
    84 Reviews


    Wow…. I’m surprised and impressed with this product. I’ve been taking aromasin (anti aromatase) for 3years. Due to price I wanted to try this product. I am very happy with it so far.

  16. Rated 5 out of 5
    84 Reviews


    This product is awesome, I’ve been struggling with what to use, this blows everything else away!

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