NutraBio PRE Extreme


NutraBio PRE Extreme is the hardcore and ultra-high stim version of our original PRE formula. On top of the time tested and research proven ingredient profile already found in PRE; we added 15,000 mg of Cluster Dextrin and 4 mg of Yohimbine HCL to PRE Extreme in order to rapidly supply working muscles with fuel (glycogen) and take your energy and focus to the next level

Brand: NutraBio
Size: 20 Servings

Brand: NutraBio
Size: 20 Servings

NutraBio PRE Extreme is one of the most effective, highest quality pre-workouts on the market. The new formula includes 15 grams of cluster dextrin for enhanced training energy! One look at the 100% transparent label and well-dosed ingredients will convince you that this is the ultimate pre-workout!

  • Features 15 Grams of Cluster Dextrin®
  • Powerful Stim Complex Dramatically Increases Energy & Focus
  • Increases Strength and Power
  • Increases Endurance
  • Promotes Insane Pumps
  • 6 Grams Citrulline Malate per Serving
  • 3.5 Grams Leucine per Serving
  • No Proprietary Blends and Absolutely 100% Full Label Disclosure.


It seems like the number of new “revolutionary” pre-workouts just keeps coming – one look at the store shelves and the choices are overwhelming, to say the least! The thing is, most of these new (and old) pre-workouts are over-hyped and under-dosed. We knew we had the most effective pre-workout on the market with PRE, but we wanted to bring something more to the table…. So we created PRE-Extreme!

What makes PRE-Extreme different? We’ve added 15 grams of advanced Cluster Dextrin® to our already innovative formula! Of course, there are absolutely no proprietary blends, hidden ingredients, or unneeded fillers in PRE-Extreme – you expect nothing less from NutraBio! We use only clinically dosed and research-proven ingredients that have been clinically validated to optimize workout performance and give you real results. Bodybuilders and athletes understand that the most result-producing workouts are achieved by a combination of strength, energy, in-training endurance, a great pump, and focus. Our original PRE delivers all of these benefits and it does so better than all of those other pre-workouts on the market – and we’re continuing the trend with PRE-Extreme, the newest member of our pre-workout family!

PRE-Extreme is a synergistic combination of ingredients that will help get you ready for your toughest workouts by dramatically increasing training endurance, increasing energy with a powerful stimulant complex, enhancing the critical mind-muscle connection, and increasing muscular strength and power. You’ll experience insane pumps from the increased blood flow that will also drive much-needed oxygen and nutrients into the working muscles, which will help keep you going, no matter how intense your workout is.



Cluster Dextrin® (Highly Branched Cyclic Dextrin) – The importance of carbohydrates is something elite athletes understand. The stored carbohydrate in the form of glycogen is what your muscles use for fuel, without adequate supply, your training performance grinds to a halt, no matter how strong the stimulant complex! This is the reason we decided to include Cluster Dextrin®, or highly branched cyclic dextrin (also in our Super Carb). Cluster Dextrin® is the most advanced carbohydrate source you can buy. One key feature is the capability to pass through your stomach quickly, thereby supplying your muscles with an even flow of glycogen to extend training endurance and enhance performance. The rapid stomach clearance is because of a mechanism known as "low osmolarity," a process that allows quick transport through the stomach. The primary advantage of this is that by providing cellular energy before your training means you won't “hit the wall” during your training. PRE-Extreme is the only pre-workout on the market that contains Cluster Dextrin® in a properly dosed, effective amount. Compared to those other expensive sports nutrition carb formulas, Cluster Dextrin® mixes easily and has greater solubility, there’s no hidden dextrose or maltodextrin, only pure Cluster Dextrin®.

L-Citrulline(HPLC) - 6000 mg - L-citrulline is converted into L-arginine in the body which then activates nitric oxide pathways and the blood vessel vasodilation. This means you get stunning pumps and increased nutrient/oxygen delivery to your working muscles. Research has validated that supplementing 6 grams per day of citrulline malate increases the body’s production of ATP (your body’s primary energy source) by 34%, slows muscle fatigue, and increases workout performance. NutraBio's citrulline malate is fully reacted and in the clinically proven ratio of 2:1.

CarnoSyn® Beta-Alanine (HPLC) – 3.2 grams – A variation of the amino acid alanine, this compound works indirectly by acting as a precursor to carnosine, thereby increasing muscle carnosine content which in turn buffers lactic acid, slows fatigue and dramatically improves workout endurance. In fact, clinical studies have shown an increase in training ability of up to 4 minutes as a result of beta-alanine supplementation – this means you can pound out more reps and more sets!

L-Leucine - 3500 mg – As most everyone knows, leucine has earned a reputation as the most anabolic of the three BCAAs. It has been shown to effectively stimulate muscle protein synthesis, which is the process of recovery and consequently muscle growth.
Clinical studies have shown that supplementation with at least 2 grams of leucine per day will increase muscle growth, reduce muscle soreness, and decrease between workout recovery time. Furthermore, in 2012, Howatson et al. discovered that leucine, as part of a complete BCAA formula taken before intense resistance workouts, decreased muscle damage, and reduced recovery time in healthy male test subjects.
At NutraBio, we only use leucine that is derived from fermented vegetable sources instead of animal-based sources.

BETAINE ANHYDROUS - 2500 mg - Betaine, more properly known as trimethylglycine (or TMG), is a metabolite of choline that carries out two primary functions in the body - as a methyl donor and as an osmolyte. Functioning as a methyl donor, betaine converts homocysteine to L-methionine and is actually a creatine precursor. Functioning as an osmolyte, betaine primarily protects proteins, cells, and enzymes from excessive heat and dehydration. Additionally, Betaine contributes to muscle protein synthesis and may increase levels of nitric oxide. Clinically suggested doses of 1.25 grams used in a study conducted by the University of Connecticut have been shown to increase bench press power by 20% and doses of 2500-6000 mg of betaine per day have been shown to increase muscular strength, in-training endurance, and total training volume.

PHARMAPURE CREATINE MONOHYDRATE - 3000 mg – Everyone knows how effective and research-proven creatine is, so much so that it goes without saying. However, not everyone may know exactly what creatine is. It’s actually a nitrogenous organic acid produced in the body that plays a major role in the ATP energy system by acting as the main fuel source for short-duration, high-intensity activities such as weightlifting or sprinting. It’s mainly stored in muscle tissue, and it’s used for resynthesizing ADP into ATP. So when our muscles use up their energy stores, creatine steps in to quickly replenish those stores. Additionally, creatine has been clinically proven time and time again to increase lean muscle, strength, power, and muscular endurance. It also contributes to muscle cell hydration. If that’s not enough, the newest research indicates it may promote cognitive benefits. The International Society of Sports Nutrition’s stance on creatine monohydrate is that short-term use has been shown to improve work output during peak effort sets by 5–15%, power output and strength by 5–15%, work output during a single effort sprint by 1–5%, and work output during repetitive sprints by 5–15%. Longer-term use improves overall training quality with a 5 to as much as 15% improvement in strength and performance.
We also use Creatine HCL in PRE because it’s more soluble than regular creatine monohydrates and in theory is absorbed more completely, which means you need less to achieve the same results.


Taurine - 2 g – This amino acid is perhaps best known for its positive effects on the heart and cardiovascular system. Additionally, research indicates that taurine, when combined with caffeine, improves mental alertness and focus. Taurine becomes depleted during times of physical exertion, which means it must be replenished from diet and supplementation.
Taurine is also involved in the regulation of water balance in the body and in the regulation of core body temperature.
In a study conducted in 2004, Zhang et al. discovered that test subjects taking taurine for one week before intense exercise dramatically improved time to exhaustion, VO2 max, and overall work output.

CALCIUM POTASSIUM PHOSPHATE CITRATE (CALCI-K) - 525 mg and SODIUM PHOSPHATE - 189mg - Calcium, potassium, and phosphorus are three critical electrolytes required by the body to maintain proper body water balance and motor neuron function. When we exert ourselves, as in an intense exercise or athletic session, we lose electrolytes as we sweat. To prevent reduced performance, these electrolytes absolutely must be replaced. Electrolyte intake during intense exercise prevents muscle cramps and is critical to the ability to perform normal muscular contractions. In 2007, Sims et al. found that consuming a high-sodium liquid before intense exercise increased plasma volume and lowered perceived strain during the exercise session. Additionally, the drink increased work output in warm conditions. NutraBio uses CALCI-K in PRE-Extreme, the combination of electrolytes in CALCI-K are highly soluble and rapidly absorbed.


N-Acetyl-L-Tyrosine - 1500 mg - An essential amino acid, Tyrosine acts as the precursor to thyroxine and the hormones epinephrine, norepinephrine, and dopamine. Often used synergistically with caffeine in pre-workouts and energizers, Tyrosine enhances mental alertness, focus, and mood by increasing levels of catecholamines in the blood. Also, Tyrosine enhances endurance and workout performance by regulating metabolism and key neurotransmitters. A clinical study conducted at the Naval Aerospace Medical Research Laboratory found that a dose of L-tyrosine provided to sleep-deprived test subjects improved psychomotor performance that would normally decrease as the test subjects become mentally fatigued.

CAFFEINE - 250 mg - and INFINERGY DI-CAFFEINE MALATE – 100mg - 350 mg Total Caffeine – Without a doubt the most widely used and most popular energy compound in the world, caffeine is also one of the most clinically-proven performance-enhancing compounds on the market. Typical uses for caffeine include energy, focus, and cognitive enhancement. As well, it has been effectively used to improve in-workout endurance. Additionally, caffeine is a very popular fat loss compound and for good reason, as it has been clinically shown to promote a thermogenic effect as well as increase the use of fats for energy. Dicaffeine Malate is a complex of caffeine and malic acid. The addition of malic acid lowers the potential of negative digestive effects associated with caffeine, lowers the sense of a caffeine crash, and slows the development of tolerance to caffeine. Clinical studies have indicated that high doses of caffeine, such as 250-450 mg, are required to produce the most significant performance benefits. The ISSN stance on caffeine is that: Caffeine enhances alertness during times of intense physical exercise, specifically exercise that requires extended focus and concentration. Additionally, caffeine is a potent performance aid for extended endurance workouts or events conducted at a peak level. Furthermore, caffeine will enhance glycogen replenishment during periods of post-workout recovery.

THEAPURE (L-THEANINE) - 300 mg - L-theanine is an amino acid that, once in the body, manufactures glutamate and GABA, two neurotransmitters that help lower perceived stress. Clinical research has indicated that L-theanine has the ability to take the "edge" off of other stimulants, creating a smoother, cleaner energy sensation.
In a clinical study conducted by Giesbrecht et al., it was discovered that a complex of caffeine and L-theanine dramatically improved task accuracy and increased alertness.

HUPERZINE A - 100 mcg – This compound prevents the breakdown of acetylcholine, an important neurotransmitter in the central nervous system involved in cognition and muscular contractions. It also increases acetylcholine levels, enhancing focus, improving mood, and improving memory. In 1999, a study conducted by Sun et al. (1999) indicated that test subjects who supplemented with Huperzine A for a month improved memory retention and learning performance when compared to test subjects taking a placebo.


Agmatine Sulfate - 1000 mg – This compound is an arginine byproduct as a result of the process of decarboxylation. In this decarboxylated state, arginine cannot be broken down by the body so it instead increases blood flow to your working muscles, thereby enhancing the pump and increasing delivery of needed nutrients to the working muscles. Also, agmatine has been clinically suggested to manipulate pain receptors, allowing you to train past the typically perceived pain. At NutraBio, we only use a vegan source of agmatine that is derived from fermented plants.

INOSITOL ARGININE SILICATE (AS NITROSIGINE) - 750 mg – A relatively new ingredient in the supplement world, Nitrosigine is a combination of arginine and silicon that increases levels of nitric oxide more than arginine are able to do by itself. This, of course, means a synergistic action with agmatine sulfate and citrulline malate to produce greater pumps and increased nutrient and oxygen delivery to the working muscles. Clinical studies have suggested that nitrosamine is more biologically active than arginine chloride and demonstrates an enhanced blood flow during and after exercise.


As you can see, PRE-Extreme is better than other pre-workouts because we use clinically proven ingredients that are properly dosed, instead of using ineffective doses of low-quality ingredients. We created this powerful pre-workout because most of the NutraBio team involved with PRE-Extreme are dedicated athletes themselves, and we wanted a formula that took the next step, leaving the rest of the pre-workout crowd behind.

For over 20 years, NutraBio has never followed the crowd, instead, we innovated the use of non-proprietary blends, clinical dosing, and researched backed ingredients, as well as featuring the most fully disclosed labels on the market, to the point of disclosing the exact amounts of flavoring and sweeteners. We have always focused on creating the best products you can buy, and PRE-Extreme is no exception. This is the most comprehensive, transparent-label, clinically dosed pre-workout available – what you read on the label is exactly what you pay for when you buy PRE-Extreme or any NutraBio product. Compare PRE-Extreme to any other pre-workout currently available and you will see that PRE-Extreme is a no-compromise, no BS formula and that even the most hyped pre-workouts cannot compare. So why wait, order a container today!


Discuss with your physician before taking if you have a medical condition or are taking any prescription medications. Stop use and discuss with your physician if any negative effects occur. Do not exceed the suggested dose. Contains caffeine. Do not use with other stimulant-based products. Do not use within 5 hours of bedtime. Do not take if pregnant or lactating. Must be 18 years old to use this product. Keep away from children. Do not use if the seal has been tampered with. Store in a cool, dry place.

Supplement Facts

20 servings per container
Serving size
1 Scoop (43.65 Grams)
Total Carbohydrate
Vitamin C (as ascorbic acid USP)
150 mg
Vitamin B3 (as niacin)
30 mg
Vitamin B6 (as pyridoxine HCI)
50 mg
Vitamin B12 (as methylcobalamin)
150 mcg
Calcium (Calci-K)
95 mg
Phosphorus (Calci-K
89 mg
Magnesium (Creatine MagnaPower)
40 mg
60 mg
Potassium (Calci-K)
250 mg
Glycogen Pre-load System
Highly Branched Cyclic Dextrin (as ClusterDextrin)
15 g
Power, Strength & Endurance Complex (14.2g)
L-Leucine (naturally fermented – vegan)(HPLC)
3.5 g
CarnoSyn Beta-Alanine (HPLC)
3.2 g
PharmaPure Creatine Monohydrate (micronized, HPLC)
3 g
Betaine Anhydrous (trimethylglycine, HPLC)
2.5 g
Malic Acid (HPLC)
1.5 g
Creatine Magnapower (Magnesium Creatine Chelate)
500 mg
Nitric Oxide Pump Matrix (7.75g)
L-Citrulline (naturally fermented)(HPLC)
6 g
Agmatine Sulfate (HPLC) 1
1 g
Nitrosigine (inositol-stabilized arginine silicate)
750 mg
Focus & Stim Matrix (2.70g)
L-Tyrosine (HPLC)
1.5 g
Choline Bitartrate (VitaCholine)(HPLC)
500 mg
350 mg
Caffeine Anhydrous USP (HPLC)
(as 133mg di-caffeine malate yielding 100mg caffeine)
TheaPure L-Theanine (HPLC)
300 mg
Yohimbine HCI (HPLC)
Huperzine A (from 10mg huperzia serrata leaf standardized extract)
100 mcg
Electrolyte & Hydration Optimizer (2.71g)
Taurine (HPLC)
2 g
Calcium Potassium Phosphate Citrate (Calci-K)
525 mg
Sodium Phosphate
189 mg

Daily Values are based on a 2,000 calorie diet.
Daily Value (DV) not established

Other Ingredients:

Flavoring (natural & artifical flavors 725mg, sucralose 220mg, acesulfame potassium 30mg,) beet powder (color) 50mg.

Global Disclaimer

Manufacturers continually change product specifications, images, descriptions, ingredients and pricing. While we try our best to keep all product information up to date, it may not reflect the latest information available from the manufacturer. Product packaging may contain different or additional information, including the product description, nutritional facts, ingredients, allergens and other information. Always read labels, warnings, and directions and other information provided with the product before using or consuming a product. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. For additional information about a product, please contact the manufacturer. Policies, pricing and item availability are subject to change without notice, and we reserve the right to limit quantities. Prices displayed are subject to final approval at the time of order fulfillment. While we do our best to make sure that all information displayed is accurate, we are not responsible for typographical errors or technical inaccuracies.

To determine tolerance, mix 1/2 scoop with 12-14oz. cold water and consume 30-45 minutes prior to your workout. Once tolerance has been determined, you can use 1 heaping scoop.

Additional information

Weight 36.9 oz
Dimensions 6 × 5 × 5 in

20 Servings