NutraBio PRE Extreme


Brand: NutraBio
Size: 20 Servings

NutraBio PRE Extreme is the hardcore and ultra-high stim version of our original PRE formula. On top of the time tested and research proven ingredient profile already found in PRE; we added 15,000 mg of Cluster Dextrin and 4 mg of Yohimbine HCL to PRE Extreme in order to rapidly supply working muscles with fuel (glycogen) and take your energy and focus to the next level

Brand: NutraBio
Size: 20 Servings

NutraBio PRE Extreme is a powerfully effective, high-quality, state-of-the-art pre-workout. One look at the fully disclosed, 100% transparent label and clinically dosed ingredients will convince you of one thing - this is the ultimate pre-workout!

NutraBio PRE Extreme Has Just Redefined The Pre-Workout Category - Again!

It seems like new “revolutionary” pre-workouts just keep coming – one look online or on store shelves and the choices are overwhelming. The thing is, most of these new (and old) pre-workouts are dramatically over-hyped and woefully under-dosed. Not NutraBio! We knew we already had the most effective pre-workout available with PRE. Yet we wanted to bring something more to the market…. so we created PRE-Extreme!

What makes NutraBio PRE-Extreme different? First, we added 15 grams of advanced Cluster Dextrin® to our cutting-edge formula! Of course, you won’t find prop blends, hidden ingredients, or unneeded fillers in PRE-Extreme. After all, this is NutraBio! We use only clinically dosed, proven ingredients that have been research-validated to maximize in-the-gym performance. We don’t give you hype and a formula dosed so low it’s laughable - we give you real results. Bodybuilders and athletes understand that result-producing workouts are achieved by a combination of several factors. These include extreme energy, greater strength, more endurance, huge pumps, and intense focus. Our original PRE delivers all of these benefits and it does so better than all of those other pre-workouts combined. The future is here with PRE-Extreme!

Don’t Take Our Word For It, Take A Closer Look At The NutraBio PRE-Extreme Formula!

NutraBio PRE-Extreme is a synergistic combination of powerful ingredients that will get you prepared for your most intense workouts by dramatically increasing training endurance and energy with a powerful stimulant complex. This enhances the critical mind-muscle connection and increases power and strength. You’ll experience insane pumps and your working muscles will be saturated with much-needed nutrients and oxygen. Exactly what you need to keep your workout going!


Cluster Dextrin® (Highly Branched Cyclic Dextrin) - 15 Grams

Elite bodybuilders and athletes understand the importance of quality carbohydrates to their training. Carbohydrates are stored in the body as glycogen. This is what your muscles use for energy. Without an adequate supply of carbs, your performance in the gym will screech to a halt, no matter how strong the stimulant complex is! 

That’s why we included Cluster Dextrin® highly branched cyclic dextrin in PRE Extreme. Cluster Dextrin® is an innovative carbohydrate source. One of the key features is its capability to rapidly pass through your stomach. This supplies your muscles with a steady stream of glycogen for energy to extend your endurance and improve your performance. The rapid stomach clearance of this exceptional carb is due to a mechanism called "low osmolarity”. That is a process allowing rapid transport through the stomach. 

The main benefit of this is by providing a quickly absorbed source of cellular energy as part of your pre-workout means you won't “hit the wall” midway through your training session. NutraBio PRE-Extreme is the only pre-workout that contains an effective dose of Cluster Dextrin®. Compare Cluster Dextrin® to those other sports nutrition carb formulas. It mixes easier and has greater solubility. Plus, there’s no dextrose or maltodextrin hidden in the formula.


L-Leucine - 3500 mg

Of course, leucine has the reputation as the most anabolic BCAA. Leucine has been shown to effectively stimulate protein synthesis, the direct trigger of muscle growth. Leucine also supports post-workout recovery. Clinical research has suggested that supplementation with at least 2 grams of leucine per day is all that’s needed. NutraBio only uses leucine derived from fermented vegetable sources instead of animal-based sources.

Beta-Alanine (HPLC) – 3.2 Grams

This ingredient is a variation of the amino acid alanine. It works indirectly by acting as a precursor to carnosine. Beta alanine increases levels of muscle carnosine which in turn buffers lactic acid. This lowers fatigue and extends workout endurance. This means you can train harder and longer!

PharmaPure Creatine Monohydrate - 3000 mg

It goes without saying how proven effective creatine is. Even so, not everyone understands what creatine is. It’s a nitrogenous organic acid made in the body. Creatine plays a key role in the ATP energy system. It acts as the primary source of energy for short-duration, high-intensity events such as lifting weights. It’s stored mainly in muscle tissue, and it’s used for resynthesizing ADP into usable ATP. That means when our muscles burn up their initial energy stores, creatine can quickly replenish those stores. In addition, creatine has been proven time after time to increase lean muscle, power, strength, and muscular endurance. It also promotes extreme muscle cell hydration. This is known as cell volume or water-based pumps. If that’s not enough, recent research suggests creatine might support cognitive function. 

The International Society of Sports Nutrition’s position stand on creatine monohydrate is as follows: short-term use has been shown to improve work output during peak effort sets by 5–15%, power output, and strength by 5–15%, work output during a single effort sprint by 1–5%, and work output during repetitive sprints by 5–15%. Longer-term use improves overall training quality with a 5 to as much as 15% improvement in strength and performance.

Betaine Anhydrous - 2500 mg

Betaine, also called trimethylglycine or TMG, is a choline metabolite that performs two primary functions in the body. First, it acts as a methyl donor. It’s also an osmolyte. As a methyl donor, betaine converts homocysteine to L-methionine and is a precursor of creatine. As an osmolyte, betaine helps protect cells, proteins, and enzymes from dehydration and excessive heat. It also increases cell volume or water-based pumps. In addition, Betaine supports protein synthesis and may promote nitric oxide production. Doses of 1.25 grams, as used by the University of Connecticut in studies, have been shown to increase bench press power by 20%. Doses of 2.5 to 6 grams taken daily show increased training volume, strength, and in-training endurance.

Creatine MagnaPower™ - 500 mg

This is a combination of creatine and magnesium, which is an essential mineral that supports muscular contractions and helps stabilize ATP. This combination enhances the impressive benefits of creatine. In addition, no loading is required with this form of creatine.


L-Citrulline - 6000 mg

Once in the body, citrulline converts into arginine. It then stimulates nitric oxide pathways and blood vessel vasodilation. That means you get massive pumps plus greater nutrient and oxygen delivery to the working muscles. In addition, citrulline helps ease muscular fatigue. 

Agmatine Sulfate - 1000 mg

Agmatine is a byproduct of arginine. It’s a result of the process of decarboxylation. In this state, the body can’t break down arginine. Instead, it instead increases blood flow to your working muscles. Of course, this promotes pumps and increased delivery of much-needed nutrients to your working muscles. As well, agmatine has been clinically shown to manipulate pain receptors. By doing that, it allows you to train beyond perceived pain. NutraBio only uses a vegan source of agmatine derived from fermented plants.

Nitrosigine® (Inositol Arginine Silicate) - 750 mg

This ingredient is a combination of arginine and silicon. It increases nitric oxide levels more than arginine can do by itself. This means it works synergistically with agmatine sulfate and citrulline to produce huge pumps and increased oxygen and nutrient delivery to the working muscles. Another benefit of nitrosigine is that it extends the pump up to 6 hours. 


N-Acetyl-L-Tyrosine - 1500 mg

This compound is an essential amino acid that acts as a precursor to neurotransmitters epinephrine, norepinephrine, and dopamine. It’s usually used synergistically with caffeine in pre-workouts because it increases focus, mental alertness, and mood. In addition, tyrosine improves endurance and workout performance by regulating metabolism and the neurotransmitters mentioned above. A study conducted at the Naval Aerospace Medical Research Laboratory discovered that a dose of L-tyrosine given to test subjects who were sleep-deprived improved psychomotor performance. This marker would normally decrease as test subjects become more mentally fatigued.

Caffeine - 250 mg - And Infinergy™ Di-Caffeine Malate – 100 mg - 350 mg Total Caffeine

Caffeine is beyond any doubt the most popular and commonly used energy compound in the world. It’s also one of the most effective and proven performance compounds currently on the market. Of course, the usual uses for caffeine include energy, focus, and cognitive enhancement. In addition, it has been used to extend endurance. Plus, it has been clinically shown to act as a thermogenic. To this end, it also increases the body's use of fats for energy. 

Infinergy Dicaffeine Malate is a combination of caffeine and malic acid. Adding malic acid to the mix helps reduce potential adverse digestive effects that often come with caffeine. It also helps decrease the sense of a caffeine crash. Finally, it helps slow tolerance to caffeine. 

Studies have suggested that doses of caffeine in the 250-450 mg range are needed to produce optimal performance benefits. The ISSN position stand on caffeine is as follows: Caffeine enhances alertness during times of intense physical exercise, specifically exercise that requires extended focus and concentration. Additionally, caffeine is a potent performance aid for extended endurance workouts or events conducted at a peak level. Furthermore, caffeine will enhance glycogen replenishment during periods of post-workout recovery.

Theapure™ L-Theanine - 300 mg

Once in the body, this amino acid produces glutamate and GABA. These are two neurotransmitters that help lower perceived stress. Clinical studies have suggested that L-theanine takes the "edge" off of other stimulants. This, in turn, creates a smoother, cleaner energy experience.

Huperzine A - 100 mcg

Huperzine prevents acetylcholine breakdown. Of course, acetylcholine is an important neurotransmitter that’s involved in cognitive function and muscular contractions. Also, huperzine increases acetylcholine levels, which elevates focus, enhances mood, and improves memory. In a 1999 study that was conducted by Sun et al., it was indicated that test subjects who supplemented with Huperzine A for a month improved memory retention and learning performance when compared to test subjects taking a placebo.


Taurine - 2 g

This is a type of amino acid that has positive benefits on the heart and cardiovascular system. Also, research suggests that when combined with caffeine, taurine can improve mental focus and alertness. Taurine is depleted during intense workouts and physical effort. That means it needs to be replenished from your diet and from supplements. Also, taurine is involved in the regulation of the body’s water balance and in core body temperature regulation.

In a study conducted by Zhang et al. in 2004, it was discovered that test subjects taking taurine for one week before intense workouts dramatically improved their time to exhaustion, VO2 max, and overall work output.

Calcium Potassium Phosphate Citrate (Calci-K) - 525 mg And Sodium Phosphate - 189 mg

The electrolyte minerals calcium, potassium, and phosphorus are required by the body for proper body water balance and motor neuron function. When we exert ourselves, as in intense training sessions, we lose electrolytes as we sweat. This can lead to dehydration, decreased performance, and impaired cognitive function. Therefore, the electrolytes must be replaced asap. Replacing electrolytes during intense training helps prevent muscle cramps. Plus, they are critical to your ability to perform normal muscular contractions. 

In 2007, a study conducted by Sims et al. found that consuming a high-sodium liquid before intense exercise increased plasma volume and lowered perceived strain during the exercise session. In addition, this drink increased work output in warm training conditions. 

NutraBio PRE Extreme - We Don’t Imitate, We Innovate.

PRE-Extreme stands above the crowd because we use research-proven, clinically-dosed ingredients. We aren’t like those other companies that use ineffective doses of low-quality ingredients. NutraBio created this powerful pre-workout because we are dedicated athletes ourselves. We wanted a formula that took the next step.

NutraBio innovated the use of non-prop blends, clinical dosing, and clinically backed ingredients. NutraBio also features the most fully transparent labels on the market. You can be sure we have always focused on creating the absolute best products you can buy. PRE-Extreme is no exception. It’s the most complete, balanced, transparent, clinically dosed pre-workout available. The ingredients you read on the label are exactly what you get when you buy PRE-Extreme. Go ahead and compare NutraBio PRE-Extreme to any other pre-workout currently available. You will quickly see that PRE-Extreme is a no-nonsense, no-BS formula. Even the most hyped pre-workouts cannot compare. So why wait, order yours today!

NutraBio PRE Extreme Features

  • 15 Grams of Cluster Dextrin®
  • Powerful Stim Complex For Intense Energy & Focus - Includes 350 mg Caffeine
  • Increases Power And Strength
  • Extends Endurance
  • Promotes Massive Pumps
  • 6 Grams of Pure Citrulline Per Serving
  • 3.5 Grams of Leucine Per Serving For Maximum Protein Synthesis
  • No Prop Blends - Full Clinical Dosing - 100% Full Label Disclosure.


Supplement Facts

20 servings per container
Serving size
1 Scoop (43.65 Grams)
Total Carbohydrate
Vitamin C (as ascorbic acid USP)
150 mg
Vitamin B3 (as niacin)
30 mg
Vitamin B6 (as pyridoxine HCI)
50 mg
Vitamin B12 (as methylcobalamin)
150 mcg
Calcium (Calci-K)
95 mg
Phosphorus (Calci-K
89 mg
Magnesium (Creatine MagnaPower)
40 mg
60 mg
Potassium (Calci-K)
250 mg
Glycogen Pre-load System
Highly Branched Cyclic Dextrin (as ClusterDextrin)
15 g
Power, Strength & Endurance Complex (14.2g)
L-Leucine (naturally fermented – vegan)(HPLC)
3.5 g
CarnoSyn Beta-Alanine (HPLC)
3.2 g
PharmaPure Creatine Monohydrate (micronized, HPLC)
3 g
Betaine Anhydrous (trimethylglycine, HPLC)
2.5 g
Malic Acid (HPLC)
1.5 g
Creatine Magnapower (Magnesium Creatine Chelate)
500 mg
Nitric Oxide Pump Matrix (7.75g)
L-Citrulline (naturally fermented)(HPLC)
6 g
Agmatine Sulfate (HPLC) 1
1 g
Nitrosigine (inositol-stabilized arginine silicate)
750 mg
Focus & Stim Matrix (2.70g)
L-Tyrosine (HPLC)
1.5 g
Choline Bitartrate (VitaCholine)(HPLC)
500 mg
350 mg
Caffeine Anhydrous USP (HPLC)
(as 133mg di-caffeine malate yielding 100mg caffeine)
TheaPure L-Theanine (HPLC)
300 mg
Yohimbine HCI (HPLC)
Huperzine A (from 10mg huperzia serrata leaf standardized extract)
100 mcg
Electrolyte & Hydration Optimizer (2.71g)
Taurine (HPLC)
2 g
Calcium Potassium Phosphate Citrate (Calci-K)
525 mg
Sodium Phosphate
189 mg

Daily Values are based on a 2,000 calorie diet.
Daily Value (DV) not established

Other Ingredients:

Flavoring (natural & artifical flavors 725mg, sucralose 220mg, acesulfame potassium 30mg,) beet powder (color) 50mg.

Global Disclaimer

Manufacturers continually change product specifications, images, descriptions, ingredients and pricing. While we try our best to keep all product information up to date, it may not reflect the latest information available from the manufacturer. Product packaging may contain different or additional information, including the product description, nutritional facts, ingredients, allergens and other information. Always read labels, warnings, and directions and other information provided with the product before using or consuming a product. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. For additional information about a product, please contact the manufacturer. Policies, pricing and item availability are subject to change without notice, and we reserve the right to limit quantities. Prices displayed are subject to final approval at the time of order fulfillment. While we do our best to make sure that all information displayed is accurate, we are not responsible for typographical errors or technical inaccuracies.

To determine tolerance, mix 1/2 scoop with 12-14oz. cold water and consume 30-45 minutes prior to your workout. Once tolerance has been determined, you can use 1 heaping scoop.

Additional information

Weight 36.9 oz
Dimensions 6 × 5 × 5 in

20 Servings