What is Methoxyisoflavone?

Methoxyisoflavone is a member of the family of flavonoids (isoflavones). Isoflavones are naturally occurring, hormonally active substances found primarily in soy. Chemical modifications of isoflavones have been studied as possible alternative treatments for various conditions. One of these, ipriflavone, was developed primarily for treating osteoporosis. Methoxyisoflavone is a chemical derivative of ipriflavone but it is marketed as a bodybuilding aid.

Ipriflavone is a synthetic isoflavone which may be used to inhibit bone resorption, maintain bone density and to prevent osteoporosis in postmenopausal women. Ipriflavone does have a definite anabolic property. It's anabolic effect stems from its ability to dramatically increase nitrogen retention, independent of calorie intake. This is huge from a bodybuilding standpoint – one of the keys to growth is maintaining a positive nitrogen balance.

Going back to Methoxy, in a U.S. patent, the developers based on preliminary animal research, claim that it has muscle-building and bone-building effects without the side effects seen with anabolic steroids.

These flavones, both Methoxy and Ipriflavone, were originally discovered and patented by Chinoin, a Hungarian pharmaceutical company that did nothing more with them after completing the initial research and acquiring a patent on them. They just put it on the shelf and forgot about it! This compound was locked up with a patent that expired in 1997! When the patent expired and researchers read the paperwork-well, they were impressed!

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Benefits of Methoxyisoflavone

  • Increases protein synthesis and lean mass.
  • Helps reduce body fat.
  • Maintain healthy cholesterol levels that are already within the normal range.
  • Helps promote endurance.
  • Increases the body's ability to use oxygen.

Looking at the benefits, you can see potential to not only muscle growth but also fat loss and endurance. So this seems to be a well rounded product to be sure!

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Evidence Behind Methoxyisoflavone

While none of the original research was ever published, there is one placebo-controlled human trial on methoxyisoflavone that was published in abstract form in 2001.3. This study found that athletes who took 800 mg per day of methoxyisoflavone for 8 weeks experienced a significantly greater increase in muscle mass than those who took placebo. This study appeared in what is a called a “supplement” published in association with a prestigious journal.

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Methoxyisoflavone Supplements, Timing and Dosage

There are only a limited number of Methoxy products on the market, in fact most of the available products are formulas combining various nutrients with Methoxy. All of them come in capsule or tablet form. There are apparently very few pure Methoxy products on the market at this time. At one time, there was a protein powder based on methoxy, I can remember this product being released with quite a build-up. While it was a good product, it was over priced and tasted horrible, which are two good reasons it's no longer around. There is no real timing requirements listed on most of the product labels but since Methoxy can help increase protein synthesis, I would take one dosage post workout to help promote recovery and muscle growth – remember, protein synthesis is muscle growth, so adding this to your stack of products that help promote this event makes a lot of sense. You can take one other dosage either at any other time of the day but it should be separated by 6 hours. Some labels will suggest only one dose, follow those instructions over my suggestions. Also follow dosage instructions on the label regardless of the product.

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