The Ultimate Guide to Prohormones – Updated for 2024!

The Ultimate Guide To Prohormones

Click Here to View IPYU’s Selection of Prohormones

What are the strongest supplements on the market? The answer is simple – Prohormones. Since they were originally introduced they have been the subject of considerable controversy and numerous FDA crackdowns ever since. Controversial because some bodybuilders and potential users question how safe and “natural” they really are. The FDA has cracked down because in the eyes of the FDA (and the media) all supplements are evil. In the updated Ultimate Guide To Prohormones, we will look briefly at the history of prohormones and give you a complete rundown of what’s available in 2024. Let’s jump right in!

A Brief History

Prohormones were first introduced to the supplement market in 1996 by chemist and ErgoPharm founder Patrick Arnold. He developed the original androstenedione. I can still remember the original product and the attention it received; it took the bodybuilding world by storm! At that time, the only thing that came close to Andro was creatine, and it was really not much of a contest. 

The Launch Of 1-AD

Of course, the success of Andro opened the door for other prohormones. These included androstenediol, norandrostenediol, 1-4-androstenedione, and 5 alpha androstenediol. It wasn’t long before ErgoPharm introduced 1-AD, which converted into a hormone known as 1-testosterone. This was really the first prohormone that was considered comparable to real steroids. In fact, it was a mild version of Trenbolone Acetate.

Methylated Prohormones – M1T

Eventually, the famous methyl-1-testosterone (M1T), a methylated hormone, was introduced. Methylated meant that the liver could not break it down, yet it produced rapid gains in muscle and strength. Of course, it was the strongest prohormone on the market at the time. However, it also had the potential to cause negative side effects such as high blood pressure and liver toxicity.

Here Comes The FDA

At this time Patrick Arnold and others in the supplement industry felt that the increase of available methylated prohormones like M1T would result in significant negative publicity. As noted, these products were borderline steroids, and many felt they should not be sold as supplements. Congress got involved and passed the Anabolic Steroid Control Act of 2004. This effectively classed all prohormones on the market at the time as illegal drugs on virtually the same level as anabolic steroids.

By early 2005 they were gone from retail shelves everywhere. This started a cycle of supplement companies finding loopholes so they could get some form of prohormones back on the market. That worked until the government caught on and closed the loophole. This went on until 2014 when the Designer Anabolic Control Act was passed. This bill expanded the list of banned substances, creating more problems for the supplement industry. 

Fast Forward To 2024

What is available in 2024 are prohormones that are much safer than what was originally available. You still have to understand what they are and how to use them, of course. 

Definition of Prohormones and Mechanism of Action

A prohormone can be defined as “a precursor of a hormone, such as a polypeptide that is split to form a shorter polypeptide hormone or a steroid that is converted to an active hormone by peripheral metabolism” (1). In simple terms, a prohormone is a compound that is converted in the body into an anabolic hormone. Prohormones stimulate an effect that’s similar to but milder than anabolic steroids. These effects include accelerated muscle and strength gains and rapid fat loss. The effects are milder than steroids because of a rate-limiting effect that’s caused by the conversion.

Side Effects 

While not as pronounced as they used to be, side effects may include:

  • Liver Stress
  • Hair Loss
  • Gynecomastia (Gyno)
  • Swollen Prostate Gland
  • Higher Blood Pressure Levels
  • Sore Joints
  • Headaches
  • Gastric Discomfort

These side effects can be controlled with a proper post-cycle therapy program. This approach gives you the best results. It’s important to have your PCT in place before starting a prohormone cycle.

Also, note that Hi-Tech has come out with a prohormone that can be used as long as desired with no cycling and no PCT necessary.

Cycling Prohormones

Always make sure you take only the recommended doses when using prohormones. This ensures you’ll experience the best results with the least side effects. An average prohormone cycle will last 6-8 weeks. Beginners should use 1 prohormone for their first cycle. Advanced users will usually stack 2-4 prohormones and take on-cycle support. A 4-6-week PCT program will follow this. The two main types of cycles are bulking and cutting. 

What Does A PCT Program Look Like?

When you end your prohormone cycle, your natural hormones are out of balance. This imbalance happens because the body thinks it doesn’t have to produce and release testosterone. After all, test levels surge during a prohormone cycle. When you’ve finished your cycle, your natural test levels are low while your estrogen levels are high. You’ll need to control the excess water retention and fat gain caused by excess estrogen. Also, you’ll need to balance out your test and estrogen levels. Plus, you’ll need to control the catabolic effects of cortisol. This is how you keep your gains and you do this by stimulating natural testosterone production. That’s why you must run a PCT program immediately after your cycle is over.

The Available Prohormones in 2024

By the time you read this, the list of available products may have changed. Also, I do not intend to present an in-depth technical explanation of everything. Instead, I want this to be easy to understand and a great resource for new bodybuilders trying to understand how it all works. 


This prohormone undergoes a two-step conversion in the body. This process converts 1-Andro into 1-Testosterone. 1-Andro is a non-methylated prohormone, meaning it doesn’t convert into estrogen or DHT. You won’t experience any unwanted side effects such as bloating or gyno. Additionally, there’s little to no liver toxicity. 

What To Expect

  • Lean Muscle Increases
  • Strength Increases
  • Good For Bulking and Cutting

Side Effects

Negative effects may include acne, hair loss, prostate growth, testicular atrophy, cardiovascular problems, and increased liver and kidney values. 

1 Andro Products Include

  1. Hi-Tech-1 AD
  2. Blackstone Labs Chosen1
  3. Hi-Tech 1-Testosterone

Prohormone Blends Include

  1. Hi-Tech Anavar
  2. LG Sciences Bulk Andro Kit
  3. Hi-Tech Halodrol
  4. Blackstone Labs Metha-Quad Extreme
  5. Innovative Laboratories Monster Plexx
  6. Hi-Tech Primobolan
  7. Hi-Tech Superdrol

Also Known As

  • 1-Androsterone 
  • 1-androstene-3b-ol-17-one
  • 1-DHEA 
  • 1-Dehydroepiandrosterone
  • 3b-hydroxy-5a-androst-1-en-17-one
  • 3b-hydroxy-androst-1-ene-17-one
  • 3-hydroxy-5-androst-1-en-17-one


4-Andro undergoes a two-step conversion process to become the target hormone, testosterone. This is a “wet” prohormone which means there’s a chance of estrogen conversion. Due to possible water retention, 4-Andro is a good choice for bulking.

What To Expect

  • Impressive Muscle Mass Gains
  • Increased Strength Gains
  • Ideal For Bulking 

Side Effects

Potential side effects include water retention, fat gain, and gynecomastia. Additionally, there are reported side effects of acne and hair loss.

4-Andro Products Include

  1. Hi-Tech Andriol – It needs to be noted that this is a patented prohormone that does not need to be cycled. 
  2. Hi-Tech Androdiol
  3. Blackstone Labs Brutal 4ce

Prohormone Blends Include

  1. Hi-Tech Anavar
  2. Hi-Tech Halodrol
  3. Hi-Tech Halotestin
  4. Innovative Labs Helladrol
  5. Blackstone Labs Metha-Quad Extreme
  6. Innovative Laboratories Monster Plexx
  7. Hi-Tech Superdrol
  8. Hi-Tech Sustanon

Also Known As

  • 4-Androsterone / 4-Andro
  • 4-androstene-3b-ol-17-one
  • 4-DHEA / 4DHEA
  • 4-Dehydroepiandrosterone
  • 3b-Hydroxy-4-androsten-17-one
  • 3β-hydroxyandrost-4-en-17-one
  • 3β-hydroxy-D4-androsten-17-one


19-NorAndro is a prohormone precursor. It will convert through a two-step conversion to Nandrolone (Deca). 19-NorAndro has milder effects than most other prohormones.

What To Expect

  • Good Mass Gains
  • Increased Strength
  • Good For Stacking
  • Promotes Healthy Joints
  • Milder Than Other Prohormones

Side Effects

19 NorAndro is relatively mild so the risk of side effects is lower than those associated with testosterone-based compounds. However, water retention and decreased libido have been reported among users.

19 NorAndro Products Include

  1. Blackstone Labs Abnormal
  2. Hi-Tech Decabolin
  3. Hi-Tech Deca-Durabolin
  4. Hi-Tech Osta-Plex
  5. Hi-Tech Trenabol

Prohormone Blends Include

  1. Hi-Tech Osta-Plex

Also Known As

  • 19-Nor-Andro
  • 19 NorAndrosterone
  • 19 Nor Dehydroepiandrosterone
  • 19-Nor-DHEA
  • NorAndrost-4-ene-3b-ol, 17-one
  • 19-Norandrost-4-ene-17-on


1,4-Andro will go through a two-step conversion and convert to Boldenone. One effect of Boldenone is that it increases your appetite. This makes it a great choice for bulking. 1, 4 Andro is an ideal option for those looking to increase mass with little to no water retention.

What To Expect

  • Increases Appetite
  • Promotes Muscle Gains
  • Increases Strength
  • Great For Bulking

Side Effects

There are no major side effects from 1,4-Andro. 

1,4-Andro Products Include

  1. Hi-Tech Equibolin

Prohormone Blends Include

  1. Hi-Tech Dianabol
  2. Hi-Tech Equipoise
  3. Innovative Labs Helladrol

Also Known As

  • 1,4 AD
  • 1,4-Andro
  • 1, 4-androstadiene-3, 17-Dione
  • 1,4-Androstadienedione


A metabolite of DHEA, Epi-Andro is a popular cutting prohormone. Epi-Andro is another compound that’s milder than most other prohormones.

What To Expect

  • Promotes Dry, Lean Gains
  • Mild
  • May Promote Energy
  • Milder Than Other Prohormones

Side Effects

Epi-Andro may convert to DHT, and some users report joint discomfort.

Epi-Andro Products Include

  1. Hi-Tech Dymethazine

Prohormone Blends Include

  1. Hi-Tech Anavar
  2. Hi-Tech Halotestin
  3. Innovative Laboratories Monster Plexx
  4. Hi-Tech Superdrol
  5. Hi-Tech Winstrol
  6. Blackstone Labs Superstrol-7

Also Known As

  • 5a-Androstan-3a-ol-17-one
  • 3Beta-hydroxy-5alpha-androstan-17-one azine
  • 3-hydroxy-androstane-17-one
  • 3-Epiandrosterone
  • 3B-Hydroxy-5a-androstan-17-one
  • Isoandrosterone
  • trans-Androsterone

17beta-{1-Ketoethyl}-androstane-3-one, 17a-ol

Considered a hydroxy progestin, this is a prohormone class similar to 1-Testosterone. This compound converts into an active steroid in the body.

What To Expect

  • Supports Recovery
  • Promotes Dry, Lean Gains
  • Increases Strength
  • Increases Appetite

Side Effects

There are no real side effects with this compound, but it is still a good idea to use a liver-support product.

Prohormone Blends Include

  1. Hi-Tech Equipoise
  2. Hi-Tech Halotestin
  3. Innovative Labs Helladrol

Also Known As

  • 5aOHP: 17beta {3ketoethyl}-androstane-3-one, 17a-ol 
  • 1,4-OHP: 17beta {3ketoethyl}-androsta-1,4-diene-3-one, 17a-ol

What About Training and Nutrition?

Regarding training, I suggest using a mass program that emphasizes progressive overload and heavy, basic exercises. You can include intensity techniques such as drop sets, rest-pause, and partial reps.

That might mean performing 3 heavy sets (after warming up) of an exercise followed by 1-2 intensity sets. Working out using this approach means you shouldn’t have to do endless sets. Instead, you can work out effectively and save some time.

As far as nutrition, eat a clean, higher calorie, higher protein diet if muscle mass is your goal. However, if you are on a cutting cycle, I advocate a carb cycling approach, with 50% of your daily carbs ingested in the hours around your workouts. I also advocate a high protein intake, at least 1 gram per pound of protein.

Of course, use a good protein powder and a good pre-workout. It’s never a bad idea to use creatine, BCAA formulas, and glutamine. And, if you want to ensure estrogen levels stay in check, get a good anti-estrogen, and get a good PCT. Stop by and stock up!

Who Should Use Prohormones

Whether or not you choose to take prohormones is a choice you should make based on your goals, your progress, and your research of these products. If you are under 21, a beginner, or have less than 1 year of training experience, I would not suggest prohormones.

Why, you might ask? Beginners tend to rush everything. They quickly jump into the super-advanced routines typically used by steroid-using Pro Bodybuilders. Then they wonder why they aren’t making progress. I understand the excitement and desire of the beginner. Yet many of them never gain the foundational knowledge and experience they need before they take the next step. This means the use of prohormones. Having said that, the choice is yours and yours alone to make.

Terms You Should Know


This is the positive or building stage of metabolism. You want to be in an anabolic state as much as possible if you want to build muscle mass. Referring to prohormones, it means the growth of muscle tissue with little or no masculinization (deepening of the voice, facial hair, etc.).


Pertains to the development of male sex hormones and is responsible for things such as body hair and muscle mass.


Aromatase is an enzyme that converts an androgen into an estrogen. When the body has an excessive level of testosterone in the body, it can also increase estrogen to balance out high hormone levels.


The process of being in a caloric surplus to gain as much quality mass as possible. This process includes intense weight-lifting sessions. Any bulking program should be a “clean” bulk. That is, eat high-quality foods, and don’t just pig out on junk and fast food.


This is the tearing down or destructive phase of metabolism. A catabolic state is not where you want to be if you want to build muscle.


The process of being in a caloric deficit to lose as much body fat as possible while also holding on to as much muscle tissue as possible. Burning calories through cardio and weight training, as well as strict dieting, is the focus throughout this period.


The length of time you plan to use a prohormone.

Cycle Support

A combination of ingredients taken during the cycle to counteract potential negative effects of and protect bodily organs.


A compound that typically results in lean gains, causes very little to no water retention/bloat and has a minimal conversion to estrogen. Typically, these are more anabolic than androgenic.

PCT, or Post Cycle Therapy

After a cycle of prohormones, this protocol brings your hormones back into balance and restores normal production.


Body recomposition is the process of burning fat and building muscle at the same time.


The use of two or more compounds taken within a cycle.


A compound that has some conversion to estrogen and can cause some water retention. Typically, these are more androgenic than anabolic and usually serve as a base compound within a stack.

A Note About Estrogen

Note that not all prohormones convert to estrogen and some can reduce estrogen. Don’t let the fear of side effects scare you away from a cycle. Do your research and understand what would be best for you as an individual. AI or aromatase inhibitors help reduce the amount of estrogen in your body.


Prohormones have changed a lot since they first stormed the market back in the day. They’re definitely nowhere near steroids. Still, they can be helpful in your quest for size and strength. The choice to use them is yours. I hope this guide helps you make an informed choice.

Updated For 2024 by Jim Brewster


  1. Prohormone. (n.d.). Retrieved February 15, 2017, from
  2. DHEA. (n.d.). Retrieved February 15, 2017, from
  3. Prohormone Guide. (2017, January 02). Retrieved February 15, 2017, from

18 responses to “The Ultimate Guide to Prohormones – Updated for 2024!

  1. Great info, I currently take test boost, do you know this product? Is your product natural ingredients? Always interested in the best products to achieve my goals. I’m 57 and need to lean out more and build legs, genetically gifted on top but have to work hard to earn my legs, and always looking for any help in order to achieve this goal.

    1. Thanks for your comment. Prohormones are on the very edge of being a natural product. They are not test boosters, they’re stronger. In fact, prohormones are the strongest legal supplements you can buy. You can stack a cutting prohormone with a fat burner if you want to lean out more. They will help build your legs, but that’s also a function of training. The answer is heavy squats, with an emphasis on a full, complete range of motion. After warm-ups, try a 4 second negative, then explode out of the bottom of the movement whole maintaining perfect from and complete control. Do that for 4 reps. Next, do 5-6 regular reps. Now, do an 8-10 second negative. That’s all one set. If you aren’t working in a power rack with the pins set for safety, use a leg press. The other key is to add weight to the bar every other week. Finally, take in plenty of protein and use a good pre-workout with creatine.

        1. No doubt, SARMs are powerful compounds. I’ve seen the “which is better” articles, and I’ve seen the SARMs product hype. Ultimately, I would say that both are powerful compounds that stimulate greater test production. Which is better? If it was me, I would try them both, and all things being equal, whichever compounds gives me the result would be the most powerful…for me. Personally, I’m a big fan of prohormones. Let me know which ones you have tried, and what’s working the best for you. Thanks!

  2. Thanks for the info Jim, I would like your take on how i should go ablout taking prohormone and workout regime.
    I want to get stronger and leaner, ive always been an athlete so i got an athletic body but now im 38yrs old. Ive got stubborn belly fat n i want 2 get my bench over 315, im at 310. I get alot of compliments on how good i look but thats with a fitted shirt, i dnt look cut like ppl think with my shirt off. Would prohormones help towards those goals. I just purchased lg science 6wks bulking kit prohormone, are you familiar?
    BTW ive been taking your basic creatine, protein, arginine etc. Do you recommend taking those while on the prohormone bulking kit or not. THANKS

    1. Thanks for the question. I would add a good PCT besides what LG offers, such as 5% Nutrition Post Gear. Personally I would use a test booster like Just Test Me post cycle also. Anytime I’ve used prohormones, I’ve found the hardest part is hanging on to gains once your cycle ends. Keep your protein high, keep using the creatine, and use a good, balanced pre-workout that’s clinically dosed. I would eat a high protein, moderate carb, moderate health fat diet. Keep sugar low, but have some fruit/high glycemic carbs post-workout with your shake. If you want to gain, it should a lean gain as much as possible. The thing with prohormones is you have to eat, but you should keep it as clean as you can. The prohormones should help you stay lean if you’re eating quality food. Add weight to the bar every other week, even if it’s 2.5lbs. Two keys to getting stronger are eating enough and getting enough sleep. Lacking in either will hurt your strength. Finally, a good prohormone will promote good strength gains. But remember, you lose some of what you gained once your cycle is over. I don’t know what your routine looks like, or how often you train. However you do it, don’t over do it and make sure you recover. No recovery = no growth. You asked about a workout regime. Personally, I use a modified Stronglifts 5×5. I modified it with a rep performance approach that emphasizes the negative part of the rep. I also train quickly, with as little rest between sets as I can get away with. If you have anymore questions, please let me know.

  3. Hey man. About to star a prohormone cycle with Decabolin and Test-1. Question, is it fine to take pre-workout before training? I hit the gym at 6AM every day before work and would take the first (pro hormone) dose when waking up and the pre-workout when at the gym. Any issues with that? Thanks.

    1. Thank you for this great detailed article!
      Hello, i am practicing bodybuilding always only natural and I would like to try start a cycle with one “safe” stack/prohormone:
      it would be my first one, and i am interested to take products that should not increase DHT-levels to much (prostate growth side effects).
      – maybe you can give me a recommendation, Which one of your stacks| prohormones would you recommend to begin with in my case?
      thank you very much!

      1. A good place to start would be LG Sciences Bulk Andro Kit. I would also buy a good PCT product, such as 5% Nutrition Post Gear. Also, add 5% DIM and use it during your cycle. Finally, make sure you’re eating a high protein diet. You should also eat plenty of complex carbs. Save sugary carbs for pre and post-workout only. Train hard, but don’t neglect recovery. Remember, you grow when you’ve recovered.

  4. Great article I have just purchased my first prohormone SD matrix as friends have had great results. I was just wondering with prohormones if you decide to just take 2 cycles as a boost for plateau will all gains be lost after you stop or can they be maintained if continuing to workout frequently. I just dont want to rely on them long term.


    1. I’m glad you liked the article. Thank you! The most important thing is to follow a good PCT program. You will lose some of the gains, but by following a good PCT, you can hang on to most of them. Make sure you continue to lift heavy using basic exercises. Keep protein high, and now would be a good time to start using creatine monohydrate.

  5. hey Jim, I had the best results ever with a product called protrenazine several years back. After they took it of the market I couldn’t really find anything that was remotely close to it. Ive been out of the gym for a bit now due to a couple of surgeries. What prohormone would you recommend that is closest to the makeup of the protren?

    1. I’m not familiar with protrenazine, but the name tells me alot. There are a few options, but realize the selection is not what it used to be. You can go with Crazy Bulk Trenorol, which should be similar. Or, right here on IPYU, you will find LG Sciences Bulk Andro Kit. Another good option is the Hi-Tech Deca Stack. You’ll do good with any of these.

        1. Also, my local supplement provider informed me that the dymethazine was the new form of protren, but I never saw anything close to the results on it compared to the protren. Thanks for the help

  6. Been using Blackstone Fire & Ice Stack. I felt like I was just starting to get my stride after 8 weeks but it said not to use any longer. Can I go another 8 weeks before I take a break and do a PCT?

    1. I wouldn’t. You can try two more weeks, anything more than that and you’ll reach a point of diminishing returns. I would also think long-term and begin to set up your next cycle.
      Also, you’re about to go into PCT. Make the most of this period so you can keep the max amount of gains.

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