Laxogenin – Update 2022

What is Laxogenin

Here’s a popular ingredient that you will find by itself and in various formulas. I’m talking about the popular compound Laxogenin. Before we take a closer look at this ingredient, it’s important to understand that there has been recent regulatory news about Laxo. This news refers only to synthetic Laxogenin. This updated article will review the difference between synthetic and natural Laxogenin.  We’ll also look at the ingredient itself, and the best way to use it. Let’s go!


What Is Laxogenin

This ingredient is extracted from the Smilax plant. This plant is a genus of around 300+ species. It’s a plant steroid (or, brassinosteroid). It can be called an anabolic building block. Your body uses it as a blueprint of sorts to create its own anabolics. What could be cooler than that? (1) 

One popular species used for Laxogenin supplements is Smilax sieboldii. If you are in the market for this ingredient, look for a product with a natural plant extract of Laxogenin, such as Smilax sieboldii.

This ingredient is also known as 5 Alpha Hydroxy Laxogenin. This is the synthetic version that was recently the target of “concern” by the FDA. The agency sent a letter to a number of companies expressing concern that this version of Laxogenin is not a natural dietary supplement. Yet, this compound originates from a natural source. 

Regarding the FDA letter, they only requested reasons why companies believe 5 Alpha Hydroxy Laxogenin counts as a natural ingredient. Different companies will choose to respond differently. Some will pull and replace the ingredient. Others may attempt to justify its use. Either way, if you have a product with this version, go ahead and use it. But, expect the supplement you’re using to change formulas eventually.

What Does It Do?

Now, with recent news out of the way, what does Laxogenin do? This impressive ingredient has two main benefits. First, it can stimulate protein synthesis. This is a direct trigger of muscle growth. Second, it can increase strength. Of course, a stronger will be a bigger muscle, as long as you’re training for more size. 

It also has anti-catabolic benefits. That means it can help you stay anabolic. That makes it a powerful yet balanced natural ingredient. 

Is It A Prohormone?

No, it’s a natural product derived from plants. However, you can cycle it like a prohormone. You could also add it to your PCT program. 

As a matter of fact, like prohormones, any Laxogenin product you’ll find on will suggest running a 12-16 week cycle. Typically, that would be followed by 4-6 weeks off. This is true whether its a single-ingredient product or a formula that includes Laxogenin.

Who Can Use Laxogenin?

Anyone can use it. There have been no reported side effects. Since it’s non-hormonal, it’s safe for women as well as men. Additionally, if you’re a natural lifter, you’ll need that edge I mentioned earlier. This is a supplement that could be the edge you’re looking for. Better still, you can stack it with the rest of your supplement arsenal. That could really be a powerful arsenal!

The Best Laxogenin Supplements

Some of the best supplements available on right now include:

Hi-Tech Laxogenin 100 – One tablet supplies a huge 10mg Laxogenin. Hi-Tech suggests taking 2 per day for 16 weeks. I would expect Hi-tech to fight the FDA over this ingredient, they’re a tough company that won’t allow themselves to be pushed around.

5% Nutrition Bigger By The Day – This is a formula that pairs Laxogenin with Epicatechin, Leucine, and HICA. 5% Nutrition suggests taking 1 capsule 3 times per day. That dosing level supplies 300mg Laxogenin. No cycling is suggested. 

Future versions of Bigger By The Day will replace this ingredient with an even more powerful compound. Look for it!

Blackstone Labs Anogenin –  One capsule supplies 25 mg Laxogenin. Blackstone Labs suggests taking 2 capsules per day for an 8-12 week cycle. You’ll find that Blackstone is like Hi-Tech, they won’t be pushed around by anybody.

How To Use Laxogenin

If you’re using a product other than the three listed above, follow all label directions. I don’t suggest deviating from the label. 

Stacking Laxogenin

Of course, you’ll want to be using a foundation stack. This should consist of protein powder, a pre-workout, Creatine, and a multi, at least. On top of that, I suggest stacking it with other natural muscle builders. Examples include epicatechin, HMB, turkesterone, ecdysterone, and phosphatidic acid, to name a few. BCAAs and glutamine should also be included. 

This kind of combo creates quite a stack. Products that you’ll find on that contain these ingredients include:


As you can see, Laxogenin can be a powerful addition to your program. If more mass and strength are on your list of goals, this is the supplement for you. 

Don’t forget, while you’re choosing your formula, you can do all your supplement shopping right here:!

Click Here to see all the products containing Laxogenin on IPYU


  1. Esposito, D., Komarnytsky, S., Shapses, S., & Raskin, I. (2011, October). Anabolic effect of plant brassinosteroid. Retrieved from



Leave a Reply

Your email address will not be published. Required fields are marked *