INTRODUCING MPA VASOSEVEN
MPA VasoSeven is a topical skin gel that glides on smoothly, and dries rapidly. VasoSeven contains 7Keto® which has demonstrated in clinical trials to have a positive effect on basal metabolic rate without diet or exercise.
7-KETO HAS THE FOLLOWING EFFECT
- Makes fat loss 4x more effective than diet or exercise alone
- Activates 3 primary thermogenic enzymes (fatty acyl CoA , malic enzyme, glycerol-3-phosphate dehydrogenase)
- Increases metabolism by 5.4% Keeps the metabolism elevated during low-calorie eating
- Anecdotally demonstrated to lessen fat gain during overfeeding periods
Putting your body through the extremes of rigorous dieting practices can put immense stress on your hormonal systems. Prolonged carbohydrate restriction, which inevitably happens to achieve abnormal levels of leanness, can suppress thyroid function and ultimately hinder your metabolism.
The stress hormone cortisol is also magnified during the final stages of an extreme diet due to central nervous system (CNS) overstimulation from:
● Excessive cardio
● Resistance training
● Caffeine usage
● Yohimbine HCL usage
● Ephedrine usage
I will also note that high level competitors or gym rats that partake in the usage of performance enhancing agents will oftentimes discontinue usage or lower dosages after ending a contest preparation. This leads to a troublesome cortisol rebound effect from exogenous hormones no longer occupying the glucocorticoid receptors. This phenomenon, compounded with the severe dieting endured from the months prior, is a recipe for poor body composition aftermath.
Most people know I like to stay current with new and innovative material, whether about nutrition research, new dietary practices, or potential new supplement ingredients. However, I also don’t jump on the bandwagon prematurely and align myself with an idea, practice, or product without knowing it actually is legit.
VasoSeven is nothing new, nothing groundbreaking and surely nothing “game-changing” (gosh, I hate when supplement companies use that phrase!). In fact, the ingredient in VasoSeven is rather oldschool and has been in this industry for years.
So why am I caring about an “oldschool” ingredient that has been around for years?
The answer is simple-- because I am delivering the ingredient into tissues at a clinical dose and efficiently through percutaneous absorption --> via topical application.
7-oxo-dhea is a metabolite of the multifaceted adrenal hormone dhea. It is different than plain dhea as it’s incapable of converting into androgens and estrogens , which makes it safe to use for both men and women.
I could run on and on with all the scientific jargon dealing with 7-oxo-dhea and bore you with over-complicated charts, graphs, and numbers that is usually overlooked anyways by most antsy readers. Instead, I’ll bypass that option and get straight down to business, and condense and simplify this oldschool ingredient with a kickbutt delivery system.
Let’s start with the bad and then talk about the good.
Here is a rundown of the BAD things that happen to your endocrine system during & after extreme dieting--
Once the metabolism drops off the fat loss stops, the more the calories get cut, the worse it gets. Even worse is when testosterone levels start to decline – This is pretty much sudden death for any further fat loss.
*hormonally enhanced athletes are excluded from the testosterone suppressing effects mentioned above, except if they cease usage post dieting*
Ever get cold hands while dieting? This is the effect of a suppressed metabolism. The body stops burning calories, so body temperature drops. For the experienced dieters who have been on their fair share of strict fat-loss diets-- they are all too familiar with the following effects –• Lowered body temperature
• Overall weakness
• Lack of blood flow (joint stiffness)
• Deflated muscles
Everything slows down – blood flow, hormone production, and energy availability. It sucks. (2)
If anyone follows my personal contest endeavors or the athletes I coach -- you might be familiar with me being a big proponent of staying respectfully lean -- even in the off-season. I like my clients to approach the fragile post-contest period as precise and accurate as they do with their final few days before hitting the stage.
If they mess this small window of time up -- it could cost them their valuable “improvement season” initiation phase, which is crucial to making noteworthy lean mass gains. I know their calories have been pretty low for a decent amount of time, so I want to be cautious of over-feeding them too quickly. Adding in a multi-faceted and clinically proven ingredient like 7-Keto™ found in VasoSeven in a highly absorbable topical application will be paramount in aiding in the prevention of inactive cortisone→ converting into cortisol. That basically means that the actives in VasoSeven will block the enzyme responsible for this conversion by deactivating or “occupying” the 11b-HSD1 (11-beta-hydroxysteroid dehydrogenase) enzyme. -- This lowers cortisol production in selective tissues --- (think abs).
Where are the best places to apply VasoSeven?
I recommend applying VasoSeven onto areas of the body that displays a high concentration of the 11b-HSD1 enzyme content. This would be the abdominal region -- which is prone to subcutaneous, visceral & omental fat accumulation. Visceral adipose tissue (VAT) is the buildup of fat surrounding your organs which is often caused by excessive cortisol production and faulty insulin management. You can also apply VasoSeven to thin-skinned areas of the body -- inner arms, inner thighs,even the neck. Here are some of the cool things VasoSeven can do once it’s delivered into target tissues -
VasoSeven Ramps up Thermogenic Enzymes -Thermogenic = Heat producing
7-oxo-dhea ramps up sn-glycerol 3-phosphate dehydrogenase (GPDH) and cytosolic malic enzyme to increase thermogenesis--> via ramping up T3 potentiation. (9)
● Increases metabolism by 5.4%
● Keeps the metabolism elevated during low-calorie eating
● Anecdotally demonstrated to lessen fat gain during overfeeding periods
Other noteworthy benefits of VasoSeven --
- Increases PPAR-alpha expression
- Increases HDL (“good” cholesterol)
- Insulin sensitivity enhancement
- Visceral adipose tissue (VAT) reduction
- Immune support
I remember using several forms of 7-oxo-dhea about 12 years ago with inconsistent results until I found a version in topical application. I recall using the transdermal version during my earlier “bulking phases” and noticed something cool -- it seemed to keep me (and people I trained with) leaner. I honestly couldn’t tell you the approximate dosage that was delivered through the skin, but I would bet it was at least 100-200 mgs (which is what oral application has shown to be effective clinically.)
*Note* Clinical trials demonstrated 7keto™ at an oral dose of 100 mg twice a day to be effective in lowering cortisol, increasing thyroid, and enhancing immune system. However, oral bioavailability is low -- somewhere in the 3-5% range. Topical administration of 7-oxo-dhea will deliver anywhere from 20-30% of
active ingredients into the body. This is where you will see VasoSeven shine over oral administration.